Makuu: The Black Cultural Center is the University of Pennsylvania's focal point for student activities, ideas, outreach, and support linked to Black culture and the African Diaspora. Housed within the Division of the Vice Provost of University Life and located in the ARCH building in the heart of campus, Makuu provides a comfortable and convenient space for students to gather. Makuu's professional and student staff work daily to provide academic, cultural, and social support to students and groups, connecting them to additional resources and opportunities.

La Casa Latina is a Center devoted to developing greater awareness of Latino issues, culture and identity on Penn's campus. La Casa Latina provides a supportive environment where students are welcome to discuss and understand issues of importance to them. The Center supports students through resources and services that foster the integration of their academic, social, cultural, and community service activities to enrich their Penn experience. La Casa Latina strives to be a Center where all Latinos and non-Latinos can participate and learn from each other in order to enrich the intercultural experience of the Penn Community.

The Albert M. Greenfield Intercultural Center was established in 1984 and welcomes all students interested in fostering intercultural understanding on campus. As a site of learning through cross cultural activism, reflection, and dialogue the GIC promotes co-curricular educational and cultural programs. The Center provides support to the United Minorities Council (UMC) and to its many constituent groups. It is also home to popular intercultural programs, such as: Programs for Awareness and Cultural Education (PACE) – a diversity education program and Alliance & Understanding (AU) – an exploration into the historic partnership between Blacks and Jews during the Civil Rights era, as well as, organizations such as the Race Dialogue Project and Six Directions, the latter being an organization for students interested in Native American issues.

The International Student and Scholar Services (ISSS) is an office within Penn Global that aims to advance Penn’s commitment to global engagement by providing immigration expertise and services to the Penn community including UPHS. Its primary goals are to support Penn’s ability to educate, train, and hire the best and brightest international students, scholars, and staff, and faculty by providing expertise and quality service. Additionally, ISSS serves as Penn's immigration liaison with various U.S. government agencies.

The Graduate and Professional Student Assembly (GAPSA) is the official student government body for graduate and professional students at Penn, representing over 10,000 students across twelve graduate schools.